Dihexa

Preclinical

Also known as: N-hexanoic-Tyr-Ile-(6) aminohexanoic amide

Cognitive & NeuroprotectiveOralSubcutaneousIntranasal

An angiotensin IV analog reported to be 10 million times more potent than BDNF at promoting new synapse formation. Under investigation for cognitive disorders.

Molecular Weight507.6 Da
Half-Life (t½)~12 hours
SequenceHexanoyl-Tyr-Ile-Ahx-NH2

Mechanism of Action

Binds HGF (hepatocyte growth factor) receptor c-Met, promoting synaptogenesis, neuronal connectivity, and dendritic spine formation.

Dosing Protocol

Oral: 10-20 mg daily. Subcutaneous: 1-5 mg. Intranasal protocols vary. Very limited human dosing data.

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Reconstitution

Oral compound or dissolved in solution for injection.

Storage

Room temperature, dry. Solutions: 2-8°C.

Side Effects

  • Very limited human safety data
  • Potential for excessive growth factor stimulation

Key Research Findings

  • Reversed cognitive deficits in scopolamine-treated rats
  • 10^7 times more potent than BDNF at synaptogenesis in vitro
  • Restored cognitive function in aged rats to youthful levels

Latest Verified Lab Report

No lab reports available for Dihexa yet.

Community-funded testing results will appear here.

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Research Use Only

This information is provided for educational and research purposes only. It is not intended as medical advice. Always consult a qualified healthcare professional before using any research compounds.