Gonadorelin

FDA Approved

Also known as: GnRH, LHRH, Factrel

Sexual HealthSubcutaneousIntramuscularIntravenous

Synthetic gonadotropin-releasing hormone identical to endogenous GnRH. Used diagnostically and to maintain fertility during testosterone therapy.

Molecular Weight1182.3 Da

Half-Life (t½)~2-4 minutes

SequencepGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2

Mechanism of Action

Pulsatile administration stimulates LH and FSH release from anterior pituitary. Maintains gonadal function and spermatogenesis when used alongside TRT.

Dosing Protocol

100-200 mcg subcutaneous 2x daily. Used concurrently with TRT to preserve fertility.

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Reconstitution

2mg vial + 2mL BAC water = 1000 mcg/mL.

Storage

Lyophilized: -20°C. Reconstituted: 2-8°C, use within 14 days.

Side Effects

●Headache
●Nausea
●Injection site reactions
●Abdominal discomfort

Key Research Findings

●FDA-approved diagnostic for pituitary gonadotroph function
●Maintained spermatogenesis during exogenous testosterone use
●Preserved testicular volume in men on TRT

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