Humanin

Preclinical

Also known as: HN, HNG (S14G variant)

Longevity / Anti-AgingSubcutaneousIntravenous

A mitochondria-derived peptide with cytoprotective effects. Protects against oxidative stress, apoptosis, and neurodegenerative processes. Declines with age.

Molecular Weight2687.2 Da

Half-Life (t½)~30 minutes (HNG variant more stable)

SequenceMAPRGFSCLLLLTSEIDLPVKRRA

Mechanism of Action

Binds IGFBP-3 and BAX to inhibit apoptosis. Activates STAT3 and ERK signaling for cell survival. Enhances mitochondrial function and reduces oxidative stress.

Dosing Protocol

HNG (potent analog): 1-4 mg subcutaneous daily. Research protocols vary.

Open peptide calculator

Reconstitution

5mg vial + 2mL BAC water.

Storage

Lyophilized: -20°C. Reconstituted: 2-8°C.

Side Effects

●Generally well-tolerated in animal studies
●Limited human safety data

Key Research Findings

●Neuroprotective against Alzheimer's-associated amyloid-beta toxicity
●Improved glucose metabolism and insulin sensitivity
●Higher circulating levels correlate with longevity in centenarians

Latest Verified Lab Report

No lab reports available for Humanin yet.

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