MK-677

Investigational (Phase 2 completed)

Also known as: Ibutamoren, Nutrobal

Growth Hormone PeptidesOral

An orally active, non-peptide growth hormone secretagogue. Mimics ghrelin to stimulate sustained GH and IGF-1 elevation over 24 hours.

Molecular Weight528.7 Da

Half-Life (t½)~24 hours

SequenceNon-peptide (small molecule GHS receptor agonist)

Mechanism of Action

Non-peptide ghrelin receptor agonist. Oral bioavailability allows once-daily dosing. Increases GH pulsatility and raises baseline IGF-1 to youthful levels.

Dosing Protocol

10-25 mg oral once daily, typically before bed. No cycling required but monitor blood glucose.

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Reconstitution

Oral compound — no reconstitution needed. Available as capsules or liquid.

Storage

Room temperature. Protect from moisture and light.

Side Effects

●Increased appetite
●Water retention/bloating
●Elevated blood glucose
●Lethargy
●Numbness in hands

Key Research Findings

●Increased IGF-1 to youthful levels in elderly subjects (2-year study)
●Improved sleep quality and REM duration
●Maintained lean body mass during caloric deficit

Latest Verified Lab Report

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