NAD+

Supplement / Research compound

Also known as: Nicotinamide Adenine Dinucleotide, NAD IV

Longevity / Anti-AgingIntravenousSubcutaneousOral (precursors)

A critical coenzyme found in every cell, involved in energy metabolism, DNA repair, and sirtuin activation. Declines significantly with age.

Molecular Weight663.4 Da

Half-Life (t½)~1-4 hours (IV), variable (oral precursors)

SequenceDinucleotide (not a peptide — coenzyme)

Mechanism of Action

Serves as electron carrier in mitochondrial energy production. Activates sirtuins (SIRT1-7) for DNA repair and gene regulation. Substrate for PARP enzymes in DNA damage response.

Dosing Protocol

IV: 250-1000mg infused over 2-4 hours. Subcutaneous: 50-100mg daily. Oral precursors (NMN/NR): 250-1000mg daily.

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Reconstitution

100mg vial + 3mL BAC water for subcutaneous. IV supplied pre-mixed.

Storage

Protect from light. Lyophilized: -20°C. Solutions: 2-8°C.

Side Effects

●Nausea
●Flushing
●Chest pressure (IV)
●Headache
●Cramping during infusion

Key Research Findings

●NAD+ levels decline 50% between ages 40-60
●NMN supplementation reversed age-related arterial dysfunction in mice
●Sirtuin activation linked to improved healthspan in multiple models

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