VIP
Also known as: Vasoactive Intestinal Peptide, Aviptadil
A 28-amino acid neuropeptide with potent anti-inflammatory, immunomodulatory, and vasodilatory properties. Being studied for CIRS, pulmonary conditions, and autoimmune diseases.
Mechanism of Action
Binds VPAC1/VPAC2 receptors, suppressing TNF-alpha, IL-6, and NF-kB pathways. Promotes regulatory T-cells, enhances surfactant production in lungs, and dilates blood vessels.
Dosing Protocol
Intranasal: 50 mcg per nostril 4x daily (Shoemaker CIRS protocol). IV: clinical trial doses vary.
Open peptide calculatorReconstitution
Typically supplied pre-mixed for intranasal use.
Storage
Refrigerate 2-8°C. Very sensitive to degradation.
Side Effects
- ●Nasal congestion
- ●Diarrhea
- ●Hypotension (IV)
- ●Flushing
Key Research Findings
- ●Improved pulmonary function in COVID-19 ARDS (Aviptadil trials)
- ●Reduced inflammatory markers in CIRS/mold illness protocols
- ●Neuroprotective effects in neurodegenerative disease models
Latest Verified Lab Report
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This information is provided for educational and research purposes only. It is not intended as medical advice. Always consult a qualified healthcare professional before using any research compounds.